Recent research on extracts and purified compounds from the gum resin of Boswellia serrata has shed light on the bioavailability of a compound shown partially responsible for the plant’s joint health and inflammatory modulating principles.
“The recent research on Boswellia confirms that 11-keto β-boswellic acid, or KBA, may be the appropriate active biomarker to measure consumption of Boswellia extracts,” said Blake Ebersole, Technical Director of Verdure Sciences.
A human pharmacokinetic study found a single 333mg dose of WOKVEL® led to a maximum KBA plasma concentration of 2.7 micromolar. The concentration needed to cut in half the activity of 5-lipoxygenase, a primary mediator of the inflammatory process, was found to be at least 2.8 micromolar.(3)
“The findings suggest that further research on Boswellia should consider focusing on KBA as the bioactive, bioavailable plasma marker from Boswellia extracts containing natural amounts of all six active boswellic acids,” said Ebersole.
Recent Study Findings:
In a study published in February 2009, experiments in CACO-2 cell cultures measuring bioavailability through the GI tract found moderate absorption of KBA, compared to the measurement of other marker compounds from Boswellia.(4) In a 2008 study in in vivo models, KBA was detected in plasma and metabolized to hydroxylated boswellic acid derivatives, in contrast to other potential boswellic acid markers.(5) This research is consistent with prior human pharmacokinetic studies on WOKVEL® Extract indicating that (KBA) is an appropriate active plasma marker to measure consumption of Boswellia extracts.(1,2)
About WOKVEL® Extract:
Randomized, placebo-controlled clinical trials have been published on the safety and efficacy of WOKVEL® Extract, which contains a proprietary, HPLC-validated fingerprint of all six beneficial beta-boswellic acids, including KBA.(2,7,8) WOKVEL® Extract may support joint health and flexibility through regulation of 5-lipoxygenase (5-LO) synthesis.
A product of vertical integration, WOKVEL® Extract is manufactured in Verdure Sciences' hands-free, ISO 9001-2000 and HACCP facility. WOKVEL® Extract is Prop-65 compliant, pesticide-free, and Kosher- and Halal-certified. More information can be found at www.wokvel.com.
About Verdure Sciences™:
Verdure Sciences offers innovative bionutritionals through the integration of agricultural networks, manufacturing control, and university-based, cutting-edge research. With an expanding pipeline of proprietary, standardized botanical ingredients supported by pharmacokinetic, pharmacodynamic, and clinical research profiles, we work toward our unified vision to offer access to safe, effective health solutions to populations worldwide.
References:
1. Kaunzinger A. et al. J. Pharm Biomed. Anal. 2002 (28) 729-739
2. Sharma S. et al. Phytomedicine 2004 11:1255–1260.
3. Buechele, B., Simmet, T. J. Chromatogr. B 2003 795 (2), 355–362.
4. Kruger et al Eur J Pharm Sci. 2009 Feb 15;36(2-3):275-84.
5. Kruger et al. Drug Metab Dispos. 2008 Jun;36(6):1135-42.
6. Abdel Tawab, M. J. Chromatogr. Biomed. Appl. 2001 761 (2), 221–22
7. Kimmatkar N et al. Phytomedicine. 2003 Jan;10(1):3-7
8. Sontakke s. et al. Indian Journal of Pharmacology. 2007; 39(1) 27-29