EXCEPTIONAL FORMULA FOR RELIEF OF MINOR PAIN AND
SUPPORT FOR JOINT AND MUSCLE TISSUE HEALTH

SAN CLEMENTE, CA—September 26, 2003—Strengthening its leadership position as a world-class provider of pure, premium-quality nutraceuticals and medical foods, Metagenics, Inc. has been awarded a new patent for the specific combination of nutrients found in Inflavonoid Intensive Care, an all-natural, scientifically advanced nutritional supplement that relieves minor pain and promotes healthy joints and muscle tissue. Inflavonoid Intensive Care is well-suited for individuals whose joints and/or muscles are affected by physical stressors such as repetitive or high impact motion, heavy or incorrect lifting, poor posture, and a typically inactive lifestyle.

Nearly all Americans will experience minor muscle and/or joint pain during some period of their life. And with growing concern over gastrointestinal (GI)-related side effects from various conventional approaches, every healthcare practitioner should be aware of the available options. “This patent reinforces our ongoing mission at Metagenics, which includes continuous innovation, educational services, and science-based products to promote patient health,” stated Jeff Katke, Founder and CEO of Metagenics.

Inflavonoid Intensive Care provides a standardized blend of boswellia, ginger, turmeric, and cayenne pepper—select phytonutrients that inhibit the enzymes involved in prostaglandin synthesis and support healthy, balanced eicosanoids (hormone-like compounds such as prostaglandins and leukotrienes). In particular, this unique formula contains boswellic acids which inhibit leukotriene synthesis. Cayenne pepper is traditionally used to support the circulatory and digestive systems and possesses many antioxidant properties. Inflavonoid Intensive Care also includes lemon bioflavonoid complex, quercetin, and vitamin C to provide the body’s connective tissues with powerful antioxidant protection from free radical damage. In advanced cell-line testing conducted at Metagenics’ MetaProteomics™ research center, Inflavonoid Intensive Care has been shown to inhibit PGE2 (an eicosanoid associated with minor pain) production more effectively than competitor formulas while exhibiting a high level of predicted GI safety.

“Many companies have explored the use of traditional herbal remedies for relieving minor pain and promoting healthy eicosanoid synthesis,” explained Jeffrey S. Bland, PhD, President and Chief Science Officer of Metagenics, Inc. “Metagenics has pioneered innovative process improvements to help improve safety and efficacy by standardizing premium-quality herbs with a long history of safe use in humans. Moreover, Metagenics continues to raise the bar in product quality through the uncompromising efforts of its diverse, highly experienced research staff, and a sophisticated quality control infrastructure which allows for a level of formula refinement that is difficult to match in this industry.” Inflavonoid Intensive Care is available exclusively through physicians and other licensed healthcare practitioners.

About Metagenics
Metagenics, a privately held company, was founded in 1983 with the mission to help patients achieve their genetic potential through targeted nutrition. The company is headquartered in San Clemente, CA, with its world-class Functional Medicine Research Center (FMRC) and manufacturing facility located in Gig Harbor, WA. MetaProteomics™, Metagenics’ vanguard research center located in Ithaca, NY, is dedicated to researching and evaluating the effects of natural ingredients on genetic expression and protein activity. With a talent base of over 350 employees worldwide, including a team of nearly 40 highly trained scientists and clinicians, Metagenics is helping to shape the future of the nutraceutical industry. The company is GMP (Good Manufacturing Practices) certified by the NNFA, holds multiple proprietary formula patents, and produces over 400 all-natural, research-based products to optimize health. Committed to innovative product development, research, and continuing practitioner education, Metagenics is the premier formulator and manufacturer of premium-quality nutritional supplements and medical foods sold to healthcare practitioners worldwide. For more information about Metagenics, please visit the company’s Web site at www.metagenics.com.

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